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吴侠


吴侠  副教授  硕士生导师

电子邮箱:wuxia@ecust.edu.cn

通讯地址:上海市徐汇区梅陇路130号华东理工大学实验181403

个人简介:

20087月毕业于内蒙古大学,获理学博士学位,留校工作;2009年月赴美国犹他州立大学从事博士后研究;20114-20198月在内蒙古大学省部共建草原家畜生殖调控与繁育国家重点实验室,担任干细胞与重编程课题组组长;20198月调入澳门十大正规平台网站。曾先后主持国家“863”高科技计划项目、国家自然基金地区项目、国家自然基金青年项目等国家和省部级项目。先后获得内蒙古自治区杰出青年基金、内蒙古自治区草原英才青年创新创业人才、内蒙古自治区青年科技英才计划青年科技骨干等人才类称号。完成成果鉴定1项,申请发明专利3项,其中PCT专利1项,参与教材和论著的编著3部,发表研究论文30余篇。担任中国整形美容协会干细胞研究与应用分会理事(上海)、中国整形美容协会干细胞研究与应用分会青年工作委员会副秘书长(上海)、内蒙古生物工程学会副秘书长、中国细胞生物学会会员。

研究方向:

主要从事以腺相关病毒和干细胞技术为主的基因和细胞治疗。以代谢罕见病、癌症等为研究对象,利用动物和干细胞模型进行腺相关病毒基因治疗药物的研发和安全性、有效性分析。建立腺相关病毒与干细胞联合的新型治疗技术体系,以及腺相关病毒与传统小分子化合药物联合的新型治疗技术体系。

教材与专著:

《动物解剖学、组织学与生殖生物学简明教程》,第二篇组织学概论,内蒙古大学出版社,2016.7ISBN978-7-5665-1016-7

《动物种业科技创新战略研究报告》,第十三章动物遗传育种前沿技术,科学出版社,2015.6ISBN978-03-044229-1

《哺乳动物生殖工程学》,第八章配子与胚胎发生的表观遗传学和第十六章诱导干细胞,科学出版社,2018.10ISBN978-7-03-058921-7

发表论文(#第一作者;*通讯作者):

1. Wu X#,*, Hu S, Wang L, Li Yan, Yu H*. Dynamic changes of histone acetylation and methylation inbovine oocytes, zygotes, and preimplantation embryos. J ExpZool (Mol Dev Evol). 2020;1-12.

2. Tao D#, Liang J#, Pan Y, Zhou Y, Feng Y, Zhang L, Xu J, Wang H, He P, Yao J, Zhao Y, Ning Q, Wang W, Jiang W, Zheng J, Wu X*. In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer. J Breast Cancer. 2019.27;22(3):375-386.

3. Wei Z#, Yang Z#, Wu X*, Yang H*. Screening of exosomal miRNAs derived from subcutaneous and visceral adipose tissues: underlying targets for treatment of obesity and associated metabolic disorders. Molecular Medicine Reports. 2018;18(3):3314-3324

4. Wang J#, Zhang F#, Yang H, Wu H, Cui R, Zhao Y, Jiao C, Wang X, Liu X, Wu L, Li G, Wu X*. Effect of TEAD4 on multilineage differentiation of muscle-derived stem cells. Am J Transl Res. 2018; 10(3): 998-1011.

5. Li S#, Lu X#, He H, Cui R, Wang X, Wang X, Wu X*. A novel culture system robustly maintained pluripotency of embryonic stem cells and accelerated somatic reprogramming by activating Wnt signaling. Am J Transl Res. 2017;9(10):4534-4544.

6. Wu X#,*, Song M, Yang X, Liu X, Liu K, Jiao C, Wang J, Bai C, Sun G, Liu X, Li G*. et al. Establishment of bovine embryonic stem cells after knockdown of CDX2. Sci. Rep. 6, 28343; doi: 10.1038/srep28343 (2016).

7. He Z#, Deng L, Li Y, Xiang D, Hu J, Chen Y, Wang M, Chen F, Liu C, Li W, Zi X, Wu X, Li G, Wangensteen K, Hu Y, Wang X*. Murine embryonic stem cell-derived hepatocytes correct metabolic liver disease after serial liver repopulation. Int J Biochem Cell Biol. 2012;44(4):648-58.

8. Meng Q#, Wu X#, Bunch T, White K, Sessions B, Davies C, Rickords L, Li G*. Enucleation of demecolcine-treated bovine oocytes in cytochalasin-free medium: mechanism investigation and practical improvement. Cell Reprogram. 2011 Oct;13(5):411-8.

9. Wu X#, Ouyang H#, Duan B, Pang D, Zhang L, Yuan T, Xue L, Ni D, Cheng L, Dong S, Wei Z, Li L, Yu M, Sun Q, Chen D, Lai L, Dai Y, Li G*. Production of cloned transgenic cow expressing omega-3 fatty acids. Transgenic Res. 2012; 21(3):537-43. (第一作者,影响因子2.569)

10. Wu X#, Li Y, Xue L, Wang L, Yue Y, Li K, Bou S, Li G, Yu H*. Multiple histone site epigenetic modifications in nuclear transfer and in vitro fertilized bovine embryos. Zygote. 2011 Feb;19(1):31-45

11. Wu X#, Li Y, Li G, Yang D, Yue Y, Wang L, Li K, Xin P, Bou S, Yu H*. Trichostatin A improved epigenetic modifications of transfected cells but did not improve subsequent cloned embryo development. Anim Biotechnol. 2008;19(4):211-24.

12. Xue L#, Cheng L, Su G, Kang F, Wu X, Bai C, Zhang L, Li G*. Nuclear transfer procedures in the ovine can induce early embryo fragmentation and compromise cloned embryo development. Anim Reprod Sci. 2011 Jul;126(3-4):179-86

13. Bai C#, Liu H#, Liu Y, Wu X, Cheng L, Bou S, Li G*. Diploid oocyte formation and tetraploid embryo development induced by cytochalasin B in bovine. Cell Reprogram. 2011 Feb;13(1):37-45

14. Meng Q#, Bai C#, Liu Y, Wu X, Bunch T, Li G*. In vitro development and chromosomal configuration of bovine somatic cloned embryos with nonenucleated metaphase II oocytes. Cell Reprogram. 2010 Aug;12(4):481-90

15. Guo X#, Yang D, Ao X, Wu X, Li G, Wang L, Bao M, Xue L, Bou S*. Production of transgenic cashmere goat embryos expressing red fluorescent protein and containing IGF1 hair-follicle-cell specific expression cassette by somatic cell nuclear transfer. Sci China C Life Sci. 2009 Apr;52(4):390-7.

16. Wu X#, Yu H, Li G, Bou S*. Trichostatin A improved epigenetic modifications of transgenic cells but did not improve subsequent cloned embryo development. Cell Research 2008 18:s144.


网页发布时间: 2019-10-23